Does the coronavirus merit investment, or personal, concern or consideration?

What a stupid comment!

Instead you should honestly be thanking Trump for the vaccine on hand in less than 1 years time. I hate to think what would have happened had Biden been in charge 1 year ago.

I know Biden likes to talk of everything good “In my first 100 days”. Let’s talk later…

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Latest stat: NY with 0.25% of world’s population, has recorded 1.5% of the world’s Covid-19 cases and 1.9% of the fatalities.

NY is clearly #1 here, and in the US on fatalities especially. They even lead on covering up their hard work, edging out some halfhearted efforts by FL. Thank you, Cuomo!

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Yeah. Not a surprise when Trump admin hobbled early detection and insisted there was broad surveillance and nothing to worry about, until there were massive numbers of community infections…

What does this have to do with anything?

Diseases strike with varying intensity. The intensity of the virus has varied all over the world. There have been various hotspots. It seems to have started in Wuhan. It then went all over the world and to the United States with outbreaks of varying intensity everywhere.

The handling of the virus was hobbled from the Federal level by the inactivity and malicious denials of the existence of the virus. Each state had to do as it could under the existing circumstances with no Federal plan of action and minimal support. The US became a model to the rest of the world as how not to behave during a pandemic.

Do you honestly believing denying it was real, saying it would go away, and claiming it was a hoax are good things to do in a pandemic? How about advising people to drink bleach, shine bright lights on themselves and not wear a mask?

If Biden did this right now, would you support and applaud him?

And yet NY is second in total deaths by state only slightly behind CA, which surely suffered the same handicaps of federal response. And NY has half the population of CA, so they’re basically 2x better at killing people and that’s without the hidden deaths.

The US federal response may have been lacking (most of the blame there I put on the CDC’s incompetence and bureaucracy delaying any possible test and trace containment effort due to their botched test design), but Cuomo’s nursing home policy was an unmitigated disaster.

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JNJ vaccine FDA review / authorization materials

https://www.fda.gov/media/146267/download

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The J&J vaccine is about to emerge.

Third US vaccine could raise question: Which shots are best?

Here is a lift:

The J&J shot was tested in the U.S., Latin America and South Africa at a time when more contagious mutated versions of the virus were spreading. That wasn’t the case last fall, when Pfizer and Moderna were wrapping up testing, and it’s not clear if their numbers would hold against the most worrisome of those variants.

Personally, I’m leaning in favor of this J&J vaccine. Hope I can obtain it.

Yes, just having to take the one vaccine sounds like a winner. DH & I took the maderna 2/18 & must return 3/18 for second dose.

I like that the J&J vax was subjected to scrutiny more recently than others. No casting aspersions or blame. Trump was far out ahead on vax developments generally. You cannot blame his team because the variants only came into being later. But I still like that, because J&J was a bit behind, they had testing opportunities to which the earlier players never had access.

The fact the earlier players now view as necessary need to develop add-ons to cover the new strains says a lot.

JNJ will be providing 100M doses in the US as part of Warp Speed, but they have had production issues and are behind schedule by several months. The upshot of this is they probably won’t be available in any real amount til April with the 100M expected by end of Q2.

That said, the company currently has a limited number of doses to contribute to the effort to step up the country’s vaccine rollout. It will be April before J&J begins to have substantial amounts of vaccine to feed into the distribution pipeline, Moncef Slaoui, former co-chair of Operation Warp Speed, said earlier this year.

JNJ is an adenovirus vector, so if you wanted a more traditional vaccine technology, that would be a reasonable view to choose them over PFE or MNRA. 1 shot is simpler too, although for all of these immunity builds up over time and the best results they quote are after 1-2 months post vaccine not unlike the 2 shot ones with a 5-6 week time frame for full vaccination.

However, in terms of their efficacy stats, I think this JNJ one looks 2nd tier to me behind PFE, MRNA, or NVAX, where we saw 95% efficacy numbers against the 72% seen for JNJ in the US (avoiding the variant issues that result in their lower foreign trial arm stats). JNJ confounds direct comparison by quoting their efficacy stats against moderate or severe disease (bad enough you have trouble breathing or worse), leaving out the mild cases (ie symptoms + PCR positive, but no need for hospitalization).

They did include a secondary analysis including mild cases, which showed overall trial efficacy in the high 60%’s, not broken down by region, but this was similar to their overall efficacy quoted for moderate/severe so I conclude they are likely similarly effective against mild as they are for the worse cases and hence a fair bit less good than the other vaccines. See page 29 from the FDA presentation I linked above.

Everything we’ve seen shows good but not quite as good vaccine efficacy against the major variants, and given all these vaccines are spike protein based off the Wuhan Classic version, I expect they will fair similarly. Yes, there have been more cases / lower efficacy, but the vast majority of those cases caused by variants in vaccinated people have been in the mild category.

My area is still offering homeless people priority over those who lie about their health issues, and I’m not yet bothering to lie about either of these so I won’t have to make the choice yet to the extent one was offered. But if I had a choice, I’d take one of the higher performing ones (PFE, MRNA, NVAX) over the lesser ones (AZN, JNJ). I suspect any of them will, after appropriate time to build your immunity, prevent the vast vast majority of all serious cases in both the original and variant strains, so in that sense any of these vaccines are still good ones.

JNJ recap

Backup link

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I’m pretty sure I’ve said all along that “6 feet” is an arbitrary fallacy. That there’s far too much situational context in determining the appropriate distance of separation. And some (not sure if you were one) rejected that, insisting that 6-feet is based on established science and I’m dumb and ignorant to say otherwise.

If you don’t think Vit D is reasonably effective / protective against covid, take the other side of these guys $100k wager and take your view to the bank.

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PFE trials are running for the age 12-15 group and they’re starting up the age 5-11 group. Results expected by EOY.

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School for me but not for thee, the CA Teachers Union edition.

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Not to worry. There might be a way!

Don’t like Trump at all, but this is nonsense. When the guy didn’t take the vaccine in December, he was criticized. Upon finding out that he got the vaccine in January, he’s criticized again.

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